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2024 13 v.39 2329-2333
绝经激素治疗对早发性卵巢功能不全患者氧化应激及免疫衰老的影响
基金项目(Foundation): 浙江省医药卫生科技计划项目(2020KY880)
邮箱(Email):
DOI: 10.19829/j.zgfybj.issn.1001-4411.2024.13.001
中文作者单位:

宁波大学附属第一医院妇科;

摘要(Abstract):

目的 探究绝经激素治疗(MHT)对早发性卵巢功能不全(POI)患者氧化应激及免疫衰老的影响。方法 选择2019年6月—2022年6月宁波大学附属第一医院收治的50例POI患者和50例健康围绝经期女性为研究对象,根据治疗方式分为A组(25例,健康围绝经期女性,安慰剂治疗)、B组(25例,健康围绝经期女性,MHT)、C组(25例,POI患者,安慰剂治疗)、D组(25例,POI患者,MHT)。对比4组治疗前后氧化应激指标、炎症细胞因子、免疫衰老指标及相关通路蛋白水平。结果 A组丙二醛(MDA)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSHPx)、过氧化氢酶(CAT)水平分别为(7.72±0.45)nmol/ml、(85.32±5.36)U/ml、(85.34±5.23)U/ml、(70.14±3.45)U/ml; B组MDA、SOD、GSHPx、CAT水平分别为(5.65±0.49)nmol/ml、(98.45±10.16)U/ml、(103.45±4.16)U/ml、(78.25±9.33)U/ml; C组MDA、SOD、GSHPx、CAT水平分别为(10.54±0.31)nmol/ml、(72.44±2.31)U/ml、(40.15±5.34)U/ml、(57.53±7.16)U/ml; D组MDA、SOD、GSHPx、CAT水平分别为(8.42±0.37)nmol/ml、(81.16±4.33)U/ml、(58.52±12.11)U/ml、(60.85±1.98)U/ml。4组MDA、SOD、GSHPx、CAT水平比较差异均有统计学意义(F=602.017,75.146,358.331,56.994,均P<0.05)。4组白细胞介素-6(IL-6)和肿瘤坏死因子-α(TNF-α)水平,CD4~+/CD8~+比值、CD28~+/CD57~+比值、CD28~-/CD57~-比值、CD28~-/CD57~+比值,Keap1、Nrf2、NQO1蛋白水平比较,差异均有统计学意义(均P<0.05)。结论 MHT可降低POI患者炎症细胞因子水平,改善氧化应激损伤,降低免疫细胞的衰老程度,可能与激活Keap1-Nrf2/ARE信号通路有关。

关键词(KeyWords): 绝经激素治疗;;早发性卵巢功能不全;;氧化应激;;炎症细胞因子;;免疫衰老;;通路蛋白
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基本信息:

DOI:10.19829/j.zgfybj.issn.1001-4411.2024.13.001

中图分类号:R711.75

引用信息:

[1]黄勇,李梅,范奇琪等.绝经激素治疗对早发性卵巢功能不全患者氧化应激及免疫衰老的影响[J].中国妇幼保健,2024,39(13):2329-2333.DOI:10.19829/j.zgfybj.issn.1001-4411.2024.13.001.

基金信息:

浙江省医药卫生科技计划项目(2020KY880)

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